Transcription factor, GATA-2/3 (IPR016374)

Short name: TF_GATA-2/3

Overlapping homologous superfamilies


Family relationships


GATA transcription factors mediate processes of development, differentiation, and gene expression in multiple tissues and cell types. Vertebrate GATA factors have two highly conserved zinc finger motifs and recognise a six-nucleotide motif T/AGATAG/A in target genes. They are separated into two subfamilies: 1) GATA1, GATA2, and GATA3 and 2) GATA4, GATA5, and GATA6. Members of the GATA1/2/3 subfamily are expressed in developing blood cells, where they regulate differentiation-specific gene expression in hematopoiesis [PMID: 1638017]. This entry represents the GATA2 and GATA3.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.