POU-domain transcription factor, class 3 (IPR016362)

Short name: TF_POU_3

Overlapping homologous superfamilies


Family relationships



This group represents a group of POU-domain transcription factors, brain type (class III). They are thought to be involved brain development [PMID: 2739723, PMID: 1565620].

The POU factors interact with canonical octamer sequence ATGCAAAT through its POU-specific (POU-S) domain and POU homeodomain (POU-H). The POU homeodomain of the class III factors interacts with a noncanonical target sequence in the FM enhancer, which drives transcription of Otx2, an essential player in rostral brain development [PMID: 22566684].

GO terms

Biological Process

GO:0007420 brain development
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.