Transcriptional enhancer factor, metazoa (IPR016361)

Short name: TEF_metazoa

Overlapping homologous superfamilies


Family relationships


Proteins in the transcriptional enhancer factor family (also known as TEAD family, includes TEAD 1 to 4) play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [PMID: 18579750, PMID: 19324877]. This entry includes protein Scalloped from Drosophila melanogaster which in combination with protein Vestigial promotes wing formation [PMID: 9869635], and in combination with Yorkie which promotes transcriptional activity and movement of Yorkie to the nucleus [PMID: 18313299].

GO terms

Biological Process

GO:0035329 hippo signaling

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.