Hemopexin (IPR016358)

Short name: Hemopexin

Overlapping homologous superfamilies

Family relationships



Hemopexin (HPX) is the plasma protein with the highest binding affinity to haem among known proteins [PMID: 12042069]. It binds haem and transports it to the liver for breakdown and iron recovery, after which the free HPX returns to the circulation [PMID: 2842511]. It has been suggested that HPX is mainly responsible for the transportation of haem thus preventing both haem-catalysed oxidative damage and haem-bound iron loss [PMID: 12042069].

GO terms

Biological Process

GO:0006879 cellular iron ion homeostasis
GO:0015886 heme transport

Molecular Function

GO:0015232 heme transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.