Transferrin (IPR016357)

Short name: Transferrin

Overlapping homologous superfamilies


Family relationships


Transferrins are eukaryotic iron-binding glycoproteins with the ability to bind ferric iron with high affinity in the cleft of each of two homologous lobes. They control the level of free iron in biological fluids [PMID: 3032619]. Members of the family include blood serotransferrin (siderophilin), milk lactotransferrin (lactoferrin), egg white ovotransferrin (conalbumin), membrane-associated melanotransferrin and saxiphilin from the American bullfrog (Lithobates catesbeiana), which binds to the neurotoxin saxitoxin [PMID: 1869567]. Family members that do no bind iron have also been discovered, including inhibitor of carbonic anhydrase (ICA), which strongly binds to and inhibits certain isoforms of carbonic anhydrase [PMID: 20572014].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.