Family

Chordin (IPR016353)

Short name: Chordin

Family relationships

None.

Description

This entry represents the chordin family. Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin, a BMP inhibitor, as well as BMP-2, is expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin increases BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering [PMID: 18710600].

During the development of the frog embryo, the scaffold protein Olfactomedin 1 (ONT1) recruits the Tolloid proteases to their substrate Chordin, an antagonist of BMPs. This stabilises the gradient of BMP signalling that is essential for dorso-ventral patterning in the embryo [PMID: 18775302]. This is not only the case in frogs; Crossveinless-2 (Cv2), Twisted Gastrulation (Tsg) and Chordin (Chd) are components of an extracellular biochemical pathway that regulates BMP activity during dorso-ventral patterning of Drosophila embryos, the formation of the fly wing, and mouse skeletogenesis as well [PMID: 18789316].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF