Chordin (IPR016353)

Short name: Chordin

Overlapping homologous superfamilies


Family relationships



This entry represents the chordin family. Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin, a BMP inhibitor, as well as BMP-2, is expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin increases BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering [PMID: 18710600].

During the development of the frog embryo, the scaffold protein Olfactomedin 1 (ONT1) recruits the Tolloid proteases to their substrate Chordin, an antagonist of BMPs. This stabilises the gradient of BMP signalling that is essential for dorso-ventral patterning in the embryo [PMID: 18775302]. This is not only the case in frogs; Crossveinless-2 (Cv2), Twisted Gastrulation (Tsg) and Chordin (Chd) are components of an extracellular biochemical pathway that regulates BMP activity during dorso-ventral patterning of Drosophila embryos, the formation of the fly wing, and mouse skeletogenesis as well [PMID: 18789316].

GO terms

Biological Process

GO:0007275 multicellular organism development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.