Dystrophin (IPR016344)

Short name: Dystrophin

Overlapping homologous superfamilies


Family relationships


Dystrophin anchors the extracellular matrix to the cytoskeleton via F-actin and is a ligand for dystroglycan. It is a component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilising the sarcolemma [PMID: 16710609, PMID: 11917091].

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), which is the most common form of muscular dystrophy and a sex-linked recessive disorder [PMID: 3319190].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding
GO:0002162 dystroglycan binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.