Clathrin, heavy chain (IPR016341)

Short name: Clathrin_heavy_chain

Overlapping homologous superfamilies

Family relationships



This group represents a clathrin heavy chain.

Clathrin is a triskelion-shaped cytoplasmic protein that polymerises into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of membrane proteins during endocytosis and organelle biogenesis by interacting with membrane-associated adaptor molecules. Clathrin functions as a trimer, and these trimers, or triskelions, are comprised of three legs joined by a central vertex. Each leg consists of one heavy chain and one light chain. The clathrin heavy-chain contains a 145-residue repeat that is present in seven copies [PMID: 10360576, PMID: 17702618].

GO terms

Biological Process

GO:0048268 clathrin coat assembly
GO:0006886 intracellular protein transport

Molecular Function

GO:0032051 clathrin light chain binding

Cellular Component

GO:0071439 clathrin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.