Receptor tyrosine-protein phosphatase, alpha/epsilon-type (IPR016336)

Short name: Tyr_Pase_rcpt_a/e-type

Overlapping homologous superfamilies

Family relationships


This entry represents receptor tyrosine-protein phosphatases (PTP) (EC:, including both alpha type and epsilon type. PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity [PMID: 12678847]. PTP-epsilon is a negative regulator of insulin signalling, where the cytosolic form has been shown to act in skeletal muscle [PMID: 18006633] and the receptor-type enzyme has been shown to act in primary hepatocytes and liver [PMID: 15738637].

GO terms

Biological Process

GO:0006470 protein dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.