Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor (IPR016332)

Short name: A1B_glyco/leuk_Ig-like_rcpt

Overlapping homologous superfamilies


Family relationships



This group represents alpha-1B-glycoproteins and several leukocyte immunoglobulin-like receptors. There are five domains in human alpha 1B-glycoprotein. Mongoose antihemorrhagic factor (AHF1) is a protein, which is homologous to human alpha 1BG, and a supergene family of immunoglobulins [PMID: 7597727].

Alpha-1B-glycoproteins have been found associated with a number of diseases. They have been detected in the urine of children with steroid-resistant minimal change nephrotic syndrome (SRINS) [PMID: 17959526]. It is also found associated with bladder cancer, having been detected in all tumor-bearing patient samples but not samples obtained from non-tumor-bearing individuals [PMID: 17518487]. When the 1694 bp was cloned from human liver Marathon cDNA, which is the alpha-1B glycoprotein precursor gene, it was found that it may be a novel member of immunoglobulin superfamily and could be involved in cell recognition and the regulation of cell behavior [PMID: 11985261].

Polymorphism of Alpha-1-B-glycoprotein (A1BG) has been found in the plasma of several human populations of the Indian subcontinent [PMID: 7985993].

Human leukocyte antigen-G (HLA-G) is a non-classical HLA class-I molecule that is expressed by placental trophoblast cells. HLA-G probably stimulates leukocyte immunoglobulin-like receptor B1 (LILRB1) receptors on decidual leukocytes. In this way, a foetus may affect the local maternal immune response [PMID: 18538632]. Human killer immunoglobulin-like receptor (KIR) genes are important for restraining natural killer cytotoxicity toward cells with autologous HLA, while targeting cells lacking or expressing low levels of self-HLA molecules [PMID: 18498296].

LILRB1 is expressed by most leukocytes and LILRB2 is expressed primarily by monocytes, macrophages and dendritic cells [PMID: 18538388].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.