Thrombomodulin (IPR016316)

Short name: CD141

Overlapping homologous superfamilies


Family relationships



Thrombomodulin is an endothelial cell thrombin receptor that converts thrombin from a procoagulant to an anticoagulant enzyme [PMID: 8216207, PMID: 2844823]. Thrombomodulin forms a 1:1 stoichiometric complex with thrombin that is responsible for the conversion of protein C to the activated protein CA. Protein CA scissions the activated cofactors of the coagulation mechanism, factors VA and VIIIA, and thereby reduces the amount of thrombin generated.

GO terms

Biological Process

GO:0030195 negative regulation of blood coagulation

Molecular Function

GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.