Cell division protein Cdc6/18 (IPR016314)

Short name: Cdc6/18

Overlapping homologous superfamilies

Family relationships



This group represents the cell division control protein Cdc6 and Cdc18, which are essential initiation factors for DNA replication [PMID: 11532929].

Cdc6 appears to have an important and perhaps unique dual role in S phase, it is first required for the initiation of DNA replication and then actively participates in the suppression of nuclear division. It interacts with the origin recognition complex (ORC). It targeted for degradation by the E3 ubiquitin ligase complex SCF (Cdc4) [PMID: 1600944, PMID: 9312054].

Cdc18 is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. It plays a key role in coupling S phase to start and mitosis. It acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, it is involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint [PMID: 7916658, PMID: 8521469, PMID: 9203581, PMID: 10766248, PMID: 11988741].

GO terms

Biological Process

GO:0006270 DNA replication initiation
GO:0051301 cell division

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.