Mannose-6-phosphate isomerase (IPR016305)

Short name: Mannose-6-P_Isomerase

Overlapping homologous superfamilies

Family relationships


Mannose-6-phosphate isomerase or phosphomannose isomerase (EC: (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N- and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals [PMID: 11165500]. Three classes of PMI have been defined [PMID: 8307007].

This group represents a mannose-6-phosphate isomerase.

GO terms

Biological Process

GO:0009298 GDP-mannose biosynthetic process

Molecular Function

GO:0004476 mannose-6-phosphate isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.