Anthranilate synthase component 2 (IPR016302)

Short name: Anthranilate_synth_II

Overlapping homologous superfamilies

Family relationships



This entry represents a trifunctional tryptophan biosynthesis protein found in some yeast. In Neurospora crassa the anthranilate synthase complex catalyses the first, third and fourth enzymatic reactions of the committed pathway of tryptophan biosynthesis. This heterotetrameric complex (alpa2/beta2) is composed of a monofunctional alpha-subunit or component I (the trp-2 gene product), which catalyses the formation of anthranilate using ammonia rather than glutamine, and a beta-subunit or component II (the trp-1 gene product), which is a trifunctional polypeptide bearing the glutamine amidotransferase (TrpG), indole-3-glycerol-phosphate synthase (TrpC), and phosphoribosylanthranilate isomerase (TrpF) activities [PMID: 6221060, PMID: 2147978].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004049 anthranilate synthase activity
GO:0004425 indole-3-glycerol-phosphate synthase activity
GO:0004640 phosphoribosylanthranilate isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.