Isochorismatase (IPR016291)

Short name: Isochorismatase

Overlapping homologous superfamilies

Family relationships



This entry includes a group of isochorismatase, including EntB from E. coli, PhzD from Pseudomonas fluorescens and VibB from Vibrio cholerae serotype O1.

EntB is involved in the second stage of enterobactin biosynthesis. It has a molecular weight of 35kDa, and is believed to possess bifunctional activity. Deletion studies involving EntB- mutants have shown that it is essential for virulence [PMID: 2521622].

PhzD is involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control [PMID: 21454481].

VibB is involved in the biosynthesis of the catechol siderophore vibriobactin [PMID: 22993087].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008908 isochorismatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.