Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta (IPR016280)

Short name: PLC-beta

Overlapping homologous superfamilies

Family relationships


This group represents phospholipase C-beta, also known as 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta. PLC-beta isoforms mediate the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) to propagate signals for several physiological responses [PMID: 11118617, PMID: 25193662]. This entry also includes NorpA, a phospholipase C (PLC) from Drosophila expressed in the eye. NorpA is a essential component of the phototransduction pathway in Drosophila [PMID: 2457447].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005509 calcium ion binding
GO:0004435 phosphatidylinositol phospholipase C activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.