Dual specificity protein phosphatase 12 (IPR016278)

Short name: DUSP12

Overlapping homologous superfamilies


Family relationships


Human YVH1, also known as dual specificity phosphatase 12 (DUSP12), is a cell survival phosphatase that prevents both thermal and oxidative stress-induced cell death. Furthermore, it associates with multiple ribonucleoprotein particles and may affect a variety of fundamental cellular processes [PMID: 27856639]. The enzyme is known as dual specificity protein phosphatase MPK-4 in Drosophila [PMID: 18456458]. Yeast YVH1, on the other hand, is required for a late maturation step in the 60S biogenesis pathway [PMID: 19797079].

GO terms

Biological Process

GO:0006470 protein dephosphorylation

Molecular Function

GO:0008138 protein tyrosine/serine/threonine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.