Non-receptor tyrosine-protein phosphatase 22 (IPR016276)

Short name: PTPN22

Overlapping homologous superfamilies


Family relationships



Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [PMID: 8890164].

Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) [PMID: 15273934].

GO terms

Biological Process

GO:0050856 regulation of T cell receptor signaling pathway

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.