Family

Phospholipase D, phosphatidylserine synthase type (IPR016270)

Short name: PLipase-D_PtdSer-synthase-type

Family relationships

None.

Description

This entry represents phospholipase D enzymes, such as phosphatidylserine synthase (PSS, or CDP-diacylglycerol--serine O-phosphatidyltransferase; EC:2.7.8.8) and phosphatidylglycerophosphate synthase (PGPS or CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; EC:2.7.8.5). Both these enzymes play essential roles in the regulation of membrane lipids. Membrane lipids are required for multiple roles ranging from messenger roles in signal transduction pathways to a role as substrate for many enzymes. PSS catalyses the convertion of CDP-diacylglycerol and L-serine to CMP and phosphatidylserine. PSS can be found in both eukaryotes and prokaryotes. In mammals, phosphatidylserine is produced through the exchange of L-serine with the base moieties of phosphatidylcholine (PSS 1) and phosphatidylethanolamine (PSS 2) [PMID: 15130088]. In Escherichia coli, the phosphatidylserine synthesised by PSS is rapidly converted to phosphatidylethanolamine [PMID: 15388336]. PGPS catalyses the conversion of CDP-diacylglycerol and glycerol 3-phosphate to CMP and phosphatidylglycerol.

GO terms

Biological Process

GO:0008654 phospholipid biosynthetic process

Molecular Function

GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER