Phospholipase D, phosphatidylserine synthase type (IPR016270)

Short name: PLipase-D_PtdSer-synthase-type

Family relationships



This entry represents phospholipase D enzymes, such as phosphatidylserine synthase (PSS, or CDP-diacylglycerol--serine O-phosphatidyltransferase; EC: and phosphatidylglycerophosphate synthase (PGPS or CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; EC: Both these enzymes play essential roles in the regulation of membrane lipids. Membrane lipids are required for multiple roles ranging from messenger roles in signal transduction pathways to a role as substrate for many enzymes. PSS catalyses the convertion of CDP-diacylglycerol and L-serine to CMP and phosphatidylserine. PSS can be found in both eukaryotes and prokaryotes. In mammals, phosphatidylserine is produced through the exchange of L-serine with the base moieties of phosphatidylcholine (PSS 1) and phosphatidylethanolamine (PSS 2) [PMID: 15130088]. In Escherichia coli, the phosphatidylserine synthesised by PSS is rapidly converted to phosphatidylethanolamine [PMID: 15388336]. PGPS catalyses the conversion of CDP-diacylglycerol and glycerol 3-phosphate to CMP and phosphatidylglycerol.

GO terms

Biological Process

GO:0008654 phospholipid biosynthetic process

Molecular Function

GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.