Ephrin receptor type-A /type-B (IPR016257)

Short name: Tyr_kinase_ephrin_rcpt

Overlapping homologous superfamilies

Family relationships


This entry represents type A and type B ephrin receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells [PMID: 12094214]. This binding leads to contact-dependent bidirectional signaling into neighbouring cells [PMID: 12094214]. Eph receptors play critical roles in embryonic patterning [PMID: 10730216], neuronal targeting [PMID: 11256076], vascular development and adult neovascularization [PMID: 11750881].

There are 10 EphA receptors and six EphB receptors, distinguished on sequence difference and binding preferences. They interact with the six glycosylphosphatidylinositol-linked ephrin-A ligands and the three transmembrane ephrin-B ligands, respectively [PMID: 23021982].

GO terms

Biological Process

GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Molecular Function

GO:0005524 ATP binding
GO:0005003 ephrin receptor activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.