Serine/threonine-protein kinase Rad53 (IPR016256)

Short name: Ser/Thr_kinase_Rad53

Overlapping homologous superfamilies

Family relationships


Rad53 is a protein kinase required for cell-cycle arrest in response to DNA damage. Rad53 controls the S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. It prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase Cdc5 [PMID: 10550056]. Rad53 also seems to be involved in the phosphorylation of Rph1, a zinc finger protein that acts as a damage-responsive repressor of the photolyase gene Phr1 in Saccharomyces cerevisiae (Baker's yeast) [PMID: 11809875]. The 2C type phosphatase, Ptc2, which is required for DNA checkpoint inactivation after double-strand breaks, appears to dephosphorylate Rad53 [PMID: 17325030].

GO terms

Biological Process

GO:0000077 DNA damage checkpoint
GO:0006281 DNA repair
GO:0006270 DNA replication initiation
GO:0009202 deoxyribonucleoside triphosphate biosynthetic process

Molecular Function

GO:0003688 DNA replication origin binding
GO:0004712 protein serine/threonine/tyrosine kinase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.