Pathways & interactions
Serine/threonine-protein kinase Rad53 (IPR016256)
Short name: Ser/Thr_kinase_Rad53
Rad53 is a protein kinase required for cell-cycle arrest in response to DNA damage. Rad53 controls the S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. It prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase Cdc5 [PMID: 10550056]. Rad53 also seems to be involved in the phosphorylation of Rph1, a zinc finger protein that acts as a damage-responsive repressor of the photolyase gene Phr1 in Saccharomyces cerevisiae (Baker's yeast) [PMID: 11809875]. The 2C type phosphatase, Ptc2, which is required for DNA checkpoint inactivation after double-strand breaks, appears to dephosphorylate Rad53 [PMID: 17325030].
- PIRSF000661 (Ser/Thr_PK_RAD53)