eIF-2-alpha kinase Gcn2 (IPR016255)

Short name: Gcn2

Overlapping homologous superfamilies

Family relationships



This entry represents Gcn2, a protein kinase that regulates the G1/S cell cycle checkpoint in response to DNA damage [PMID: 17890903, PMID: 17369398]. It stimulates Gcn4 translation in amino acid-starved cells by phosphorylating the alpha subunit of eIF-2 (SUI2) on 'Ser-52' [PMID: 11350982]. This entry also includes the probable serine/threonine-protein kinases ifkB and ifkC from Dictyostelium discoideum.

GO terms

Biological Process

GO:0000077 DNA damage checkpoint
GO:0006468 protein phosphorylation
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation

Molecular Function

GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.