eIF-2-alpha kinase Gcn2 (IPR016255)
Short name: Gcn2
Overlapping homologous superfamilies
- Protein kinase-like domain superfamily (IPR011009)
This entry represents Gcn2, a protein kinase that regulates the G1/S cell cycle checkpoint in response to DNA damage [PMID: 17890903, PMID: 17369398]. It stimulates Gcn4 translation in amino acid-starved cells by phosphorylating the alpha subunit of eIF-2 (SUI2) on 'Ser-52' [PMID: 11350982]. This entry also includes the probable serine/threonine-protein kinases ifkB and ifkC from Dictyostelium discoideum.
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
No terms assigned in this category.
- PIRSF000660 (Ser/Thr_PK_GCN2)