Tyrosine-protein kinase, receptor ROR (IPR016247)

Short name: Tyr_kinase_rcpt_ROR

Overlapping homologous superfamilies


Family relationships



The Ror family of receptor tyrosine kinases consists of two structurally related proteins, Ror1 and Ror2. Ror1 is a pseudokinase that acts as a substrate for the oncogenic tyrosine kinase Met [PMID: 21487037]. It is expressed during development [PMID: 11713269]. It shows no significant expression in normal adult tissues, but it is selectively overexpressed in a number of malignancies [PMID: 25835638]. Ror2 functions as a Wnt receptor required to maintain basal NMDAR-mediated synaptic transmission [PMID: 25825749]. For a time its ligand remained elusive, hence the name receptor tyrosine kinase-like orphan receptor-2 (Ror2). It is now established that Wnt5A acts a ligand for Ror2 [PMID: 18667433].

GO terms

Biological Process

GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.