Serine/threonine-protein kinase Mps1 (IPR016242)

Short name: Mps1

Overlapping homologous superfamilies


Family relationships


Mps1 is a serine/threonine-protein kinase involved in the phosphorylation of many mitotic regulators. It is required for spindle pole body (SPB) duplication and spindle checkpoint function [PMID: 7737118, PMID: 8567717]. It is involved in sister chromatid biorientation in mitosis and meiosis [PMID: 23371552]. The expression of Mps1 is regulated in a cell cycle-dependent manner, and the activity of Mps1 can be regulated through autophosphorylation [PMID: 17728254].

GO terms

Biological Process

GO:0007094 mitotic spindle assembly checkpoint
GO:0006468 protein phosphorylation
GO:0030474 spindle pole body duplication

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.