Aldehyde oxidase/xanthine dehydrogenase (IPR016208)

Short name: Ald_Oxase/xanthine_DH

Overlapping homologous superfamilies


Family relationships


This entry includes aldehyde oxidases and xanthine dehydrogenases. They are both molybdenum cofactor (Moco) containing enzymes [PMID: 17649978]. Aldehyde oxicases catalyse the reaction: aldehyde + H(2)O + O(2) = a carboxylic acid + H2O2 It binds 2 2Fe-2S clusters uses FAD and molybdopterin as cofactors. Xanthine has the same co-factors and can be converted from the dehydrogenase form (D) to the oxidase form (O). This can be done irreversibly by proteolysis or reversibly through the oxidation of sulphydryl groups. This enzyme catalyses three reactions: Xanthine + H2O + NAD+= urate + NADH Hypoxanthine + H2O + NAD+= xanthine + NADH Xanthine + H2O + O2 = urate + H2O2 In Arabidopsis thaliana, the molybdenum cofactor sulphurase ABA3 is needed for post-translational activation of aldehyde oxidase and xanthine dehydrogenase. It does this by transferring a sulphfur atom to the desulpho-molybdenum cofactor of these enzymes [PMID: 18258600, PMID: 17649978]

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.