Glycerol dehydrogenase (IPR016205)

Short name: Glycerol_DH

Overlapping homologous superfamilies


Family relationships


This entry represents two distinct enzymes: bacterial NAD-linked glycerol dehydrogenase and archaeal glycerol-1-phosphate dehydrogenase. NAD-linked glycerol dehydrogenase converts glycerol to glycerone and s NADH during glycerol metabolism [PMID: 1339360, PMID: 8132480]. Glycerol-1-phosphate dehydrogenase is responsible for the formation of the archaeal-specific glycerophosphate backbone of phospholipids, G-1-P, from glycerone phosphate [PMID: 9348086]. This is the key step in the in biosynthesis of archaeal enantiomeric phospholipids, [PMID: 9419225].

There is similarity in the structure of these enzymes despite the differences in substrate specificity and biological role [PMID: 15876564].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0046872 metal ion binding
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.