Domain

Polymerase/histidinol phosphatase-like (IPR016195)

Short name: Pol/histidinol_Pase-like

Domain relationships

  • Polymerase/histidinol phosphatase-like (IPR016195)

Description

This entry represents a PHP-like (Polymerase and Histidinol Phosphatase) domain, the catalytic site of which has four motifs with conserved histidine residues. This domain has a 7-stranded beta/alpha barrel fold; this structure shows some similarity to the TIM-barrel fold metallohydrolases. PHP-like domains are found in alpha-subunit of bacterial DNA polymerase III (EC:2.7.7.7) and family X DNA polymerases in addition to histidinol phosphatase (EC:3.1.3.15) [PMID: 17929834]. Proteins carrying a distorted (alpha/beta)7 barrel PHP-like fold include the hypothetical protein YcdX from Escherichia coli (which contains a trinuclear metal-binding site on the C-terminal side of the barrel) [PMID: 12661000], as well as ribonuclease P protein component 3 (Rnp3) (EC:3.1.26.5) from Pyrococcus horikoshii (no metal site on the C-terminal side of the barrel) [PMID: 15184052].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY