Homologous Superfamily

SPOC-like, C-terminal domain superfamily (IPR016194)

Short name: SPOC-like_C_dom_sf

Overlapping entries


This superfamily represents the Spen Paralogue and Orthologue C-terminal (SPOC) domain and its structural homologues. This domain has a closed beta-barrel fold of complex topology. Proteins that carry a SPOC-like domain include:

  • Spen proteins, such as SHARP (SMRT/HDAC1-associated repressor protein), which carry a SPOC domain at the C-terminal and an RNA-binding motif in the N-terminal; Spen proteins regulate the expression of key transcriptional effectors in diverse signalling pathways, the SHARP protein being a component of transcriptional repression complexes in both nuclear receptor and Notch/RBP-Jkappa signalling pathways [PMID: 12897056].

  • The middle domains of Ku70 and Ku80 (which includes the C-terminal alpha-helical arm and the DNA encircling insertion); the Ku heterodimer, which is composed of Ku70 and Ku80 subunits, contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway [PMID: 11493912].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.