Pathways & interactions
APOBEC/CMP deaminase, zinc-binding (IPR016192)
Short name: APOBEC/CMP_deaminase_Zn-bd
Cytidine deaminase (EC:22.214.171.124) (cytidine aminohydrolase) catalyzes the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase (EC:126.96.36.199) (dCMP deaminase) hydrolyzes dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity [PMID: 1567863, PMID: 8428902]. These two enzymes do not share any sequence similarity with the exception of a region that contains three conserved histidine and cysteine residues which are thought to be involved in the binding of the catalytic zinc ion.
- Yeast cytosine deaminase (EC:188.8.131.52) (gene FCY1) which transforms cytosine into uracil.
- Mammalian apolipoprotein B mRNA editing protein, responsible for the postranscriptional editing of a CAA codon into a UAA (stop) codon in the APOB mRNA.
- Riboflavin biosynthesis protein ribG, which converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate.
- Bacillus cereus blasticidin-S deaminase (EC:184.108.40.206), which catalyzes the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S.
- Bacillus subtilis protein comEB. This protein is required for the binding and uptake of transforming DNA.
- B. subtilis hypothetical protein yaaJ.
- Escherichia coli hypothetical protein yfhC.
- Yeast hypothetical protein YJL035c.
- PS00903 (CYT_DCMP_DEAMINASES_1)