Domain

Ribonuclease/ribotoxin (IPR016191)

Short name: Ribonuclease/ribotoxin

Domain relationships

None.

Description

This entry represents a structural domain consisting of a single helix packed against anti-parallel beta-sheet, which is found in both bacterial and fungal ribonucleases, as well as in ribotoxins such as restrictocin and alpha-sarcin.

Bacterial ribonucleases include barnase [PMID: 7078632], binase [PMID: 11976484], ribonuclease Sa [PMID: 12136142], ribonuclease Sa2 [PMID: 15213380], and cytotoxic ribonuclease Sa3 [PMID: 12228255]. Fungal ribonucleases include ribonuclease F1 [PMID: 8386773], ribonuclease T1 [PMID: 11453993], ribonuclease U2 [PMID: 7492561], and ribonuclease Ms [PMID: 8218254]. The ribotoxin restriction, a highly specific ribotoxin made by the fungus Aspergillus restrictus, cleaves a single phosphodiester bond in the 28S RNA of eukaryotic ribosomes, inhibiting protein synthesis [PMID: 8805570]. The ribotoxin alpha-sarcin selectively cleaves a single phosphodiester bond in a universally conserved sequence of the major rRNA, that inactivates the ribosome [PMID: 10843858].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding
GO:0004540 ribonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY