Homologous Superfamily

FAD-linked oxidase-like, C-terminal (IPR016164)

Short name: FAD-linked_Oxase-like_C

Overlapping entries


This superfamily represents a structural domain found at the C-terminal of several FAD-linked oxidases. This domain consists of two structural subdomains: subdomain 1 is a 2-layer a/b or 3-layer a/b/a sandwich, and subdomain 2 is either an orthogonal alpha-bundle or a second 2-layer a/b sandwich. It can be found in the following proteins:

  • Vanillyl-alcohol family, which includes the flavoprotein vanillyl-alcohol oxidase (EC: [PMID: 10585424] as well as the flavoprotein subunit of p-cresol methylhydroxylase (EC: (the other subunit being a short chain cytochrome c) [PMID: 15723539], both of these enzymes contain covalently bound FAD.
  • D-lactate dehydrogenases (EC:, EC: -cytochrome), a peripheral membrane respiratory enzyme involved in electron transfer for the energization of active transport of a variety of sugars and amino acids in bacteria [PMID: 10944213].
  • Cholesterol oxidases (EC:, a monomeric flavoenzyme that catalyses the oxidation and isomerisation of cholesterol to cholest-4-en-3-one [PMID: 11397813].
  • Cytokinin dehydrogenase 1 (EC:, which has a major role in the control of plant cytokinin hormone levels by catalysing their irreversible oxidation [PMID: 15321719].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003824 catalytic activity
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.