Sporulation initiation phosphotransferase B, C-terminal (IPR016122)

Short name: SpoOB_C

Overlapping homologous superfamilies

Domain relationships



Response regulatory proteins such as sensor kinases control a variety of environmentally induced responses in bacteria. SpoOB is a response regulator that responds to nutritional stress by inducing sporulation. SpoOB is a phosphotransferase that acts upon SpoOA using SpoOF as the phosphor-donor. Phosphorylated SpoOA ca activate sporulation-specific gene transcription [PMID: 1664534].

SpoOB has an alpha-beta core structure that resembles the histidine kinase fold, but lacks the kinase ATP-binding site [PMID: 9809070]. This domain is found at the C teminus of SpoOB, as well as in other sensor kinases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.