Homologous Superfamily

Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain (IPR016105)

Short name: Pyr-dep_his/arg-deCO2ase_sand

Overlapping entries


This entry represents a structural subdomain found in pyruvoyl-dependent histidine decarboxylase (EC: and arginine decarboxylase (EC: This subdomain consists of a 3-layer beta-beta-alpha sandwich. These proteins form heterohexamers [PMID: 11243783, PMID: 12623016].

Histidine decarboxylase catalyses the formation of histamine from histidine. It requires a pyruvoyl group for its activity. Cleavage of the proenzyme PI chain yields two subunits, alpha and beta, which arrange as a hexamer (alpha beta) 6 by nonhydrolytic self-catalysis.

Arginine decarboxylase catalyses the interconversion of arginine and agmatine plus carbon dioxide. It requires a pyruvoyl group for its activity.

GO terms

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0016831 carboxy-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.