FeS cluster insertion protein (IPR016092)

Short name: FeS_cluster_insertion

Overlapping homologous superfamilies

Family relationships


Proteins in this entry include HesB, IscA, SufA and ErpA, and appear to be scaffold proteins upon which 2Fe-2S clusters are assembled and subsequently transferred to acceptor proteins.

Several multiprotein complexes, referred to as ISC, SUF, and NIF, are known to be necessary for building and inserting Fe-S clusters into cellular targets [PMID: 16824008]. The HesB proteins are associated with the nif gene cluster. The Escherichia coli SufA protein is associated with SufS, a NifS homologue, and SufD which are involved in the FeS cluster assembly of the FhnF protein [PMID: 10322040]. The Azotobacter protein IscA (homologues of which are also found in E. coli) is associated which IscS, another NifS homologue, and IscU, a NifU homologue, as well as other factors consistent with a role in FeS cluster chemistry [PMID: 9582371]. ErpA is required, together with IscA, for the delivery of iron-sulphur clusters to the hydrogen-oxidizing [NiFe]-hydrogenases in Escherichia coli [PMID: 17698959,PMID: 22363723].

GO terms

Biological Process

GO:0097428 protein maturation by iron-sulfur cluster transfer

Molecular Function

GO:0051536 iron-sulfur cluster binding
GO:0005198 structural molecule activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.