Homologous Superfamily

Protease inhibitor, beta-barrel domain (IPR016085)

Short name: Protease_inh_b-brl_dom

Overlapping entries


This entry represents a beta-barrel domain found in the protease inhibitors staphostatin [PMID: 14621990] and metalloprotease inhibitor [PMID: 7752231].

Staphostatin A (SAV1910, SA1726) and B (SspC) are cysteine protease inhibitors belonging to MEROPS inhibitor families I57 and I58 (clan IK). They have a beta-barrel topology that act as specific inhibitors of staphopains, the major secreted cysteine proteases of Staphylococcus aureus [PMID: 15644332]. These inhibitors compete with substrate for binding at the active site of the staphopain, acting to protect intracellular proteins against proteolytic damage by prematurely folded and activated staphopains [PMID: 15716447]. They are also involved in growth capacity, viability and bacterial morphology.

Monomeric serralysin inhibitors are metalloprotease inhibitors that interact with specific metalloproteases synthesised by serralysin secretors and characterised by being plant, insect and animal pathogens. It is probable that the serralysin inhibitors protect the host from proteolysis during export of the protease. The members of this family belong to MEROPS proteinase inhibitor family I38, clan IK.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004866 endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.