Domain

SKP1 component, dimerisation (IPR016072)

Short name: Skp1_comp_dimer

Domain relationships

None.

Description

SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex [PMID: 10205047]. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [PMID: 8670864] and is also involved in the ubiquitin pathway [PMID: 9390558]. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [PMID: 7852383].

This entry represents a dimerisation domain found at the C-terminal of SKP1 proteins [PMID: 11099048], as well as in subunit D of the centromere DNA-binding protein complex Cbf3 [PMID: 12553912]. This domain is multi-helical in structure, and consists of an interlocked herterodimer in F-box proteins.

GO terms

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SUPERFAMILY