Domain

Translin, C-terminal (IPR016069)

Short name: Translin_C

Domain relationships

None.

Description

Translins are DNA-binding proteins that specifically recognise consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. They seem to recognise single-sranded DNA ends generated by staggered breaks occuring at recombination hot spots [PMID: 9013868].

Translin folds into an alpha-alpha superhelix, consisting of two curved layers of alpha/alpha topology [PMID: 12079346, PMID: 15039555]. This structure can be divided into two alpha-bundle subdomains. This entry represents the C-terminal alpha bundle subdomain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0043565 sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D