Domain

Ly-6 antigen/uPA receptor-like (IPR016054)

Short name: LY6_UPA_recep-like

Domain relationships

None.

Description

This entry represents a three-fold repeated domain in urokinase-type plasminogen activator receptor (uPAR) that occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2).

A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved domain of about 100 amino-acid residues [PMID: 1850423, PMID: 8394346]. Among these proteins, U-PAR contains three tandem copies of the domain, while all the others are made up of a single domain.

As shown in the following schematic, this conserved domain contains 10 cysteine residues involved in five disulphide bonds - in U-PAR, the first copy of the domain lacks the fourth disulphide bond.

     +------+     +------------------------+                    +---+
     |      |     |                        |                    |   |
 xCxxCxxxxxxCxxxxxCxxxxxCxxxxxxxxxxxxxxxxxxCxxxxCxxxxxxxxxxxxxxCCxxxCxxxxxxxx
  |                     |                       |              |
  +---------------------+                       +--------------+

'C': conserved cysteine involved in a disulphide bond.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam