NAD(P)-binding domain (IPR016040)

Short name: NAD(P)-bd_dom

Overlapping homologous superfamilies

Domain relationships


This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers alpha/beta/alpha, where the six beta strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:

  • C-terminal domain of alcohol dehydrogenases [PMID: 15449945]
  • Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) [PMID: 9174344]
  • N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase [PMID: 10448043]
  • NAD-binding domain of formate/glycerate dehydrogenases [PMID: 8114093]
  • N-terminal domain of sirohaem synthase [PMID: 14595395]
  • N-terminal domain of lactate dehydrogenase [PMID: 11276087]
  • N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) [PMID: 17222187]
  • C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix [PMID: 8591026]
  • NAD-binding domain of certain potassium channels [PMID: 11301020]
  • C-terminal domain of the transcriptional repressor Rex [PMID: 15642260]
  • Ornithine cyclodeaminase [PMID: 15518536]
  • CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase [PMID: 9917402]

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.