Domain

GDNF/GAS1 (IPR016017)

Short name: GDNF/GAS1

Domain relationships

None.

Description

This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons [PMID: 16551639, PMID: 9192899]. GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity [PMID: 9192898].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART