Conserved Site

Phosphoenolpyruvate carboxykinase (ATP), conserved site (IPR015994)

Short name: PEPCK_ATP_CS

Description

Phosphoenolpyruvate carboxykinase (ATP) (EC:4.1.1.49) (PEPCK) [PMID: 1701430] catalyses the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate while hydrolysing ATP, a rate limiting step in gluconeogenesis (the biosynthesis of glucose).

This conserved site represents a highly conserved region that contains four acidic residues and which is located in the central part of the enzyme. The beginning of this conserved site is located about 10 residues to the C terminus of an ATP-binding motif 'A' (P-loop) and is also part of the ATP-binding domain [PMID: 8609605].

GO terms

Biological Process

GO:0006094 gluconeogenesis

Molecular Function

GO:0005524 ATP binding
GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns