Homologous Superfamily

Methane monooxygenase, gamma chain, domain 2 (IPR015953)

Short name: Me_mOase_g_dom2

Overlapping entries


Methane monooxygenases (EC: catalyse the oxidation of methane to methanol in the presence of oxygen and NADH in methanotrophs. It has a broad specificity, hydroxylating many alkanes, and converting alkenes into the corresponding epoxides. In additional reactions, CO is oxidized to CO2, ammonia is oxidized to hydroxylamine, and some aromatic compounds and cyclic alkanes can also be hydroxylated, although more slowly. In Methylococcus capsulatus there are two forms of the enzyme, a soluble and a membrane-bound type. The soluble form consists of 3 components, A, B and C. Protein A is made up of 3 chains, alpha, beta and gamma.

Structurally, the gamma chain of methane monooxygenases contain two domains, each consisting of a three helices arranged in an open bundle topology [PMID: 11456616, PMID: 9329079]. This superfamily represents one of two alpha-bundle domains found in the gamma chain.

GO terms

Biological Process

GO:0015947 methane metabolic process

Molecular Function

GO:0015049 methane monooxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.