Pathways & interactions
PUA-like superfamily (IPR015947)
Short name: PUA-like_sf
- PUA domain (IPR002478)
- EVE domain (IPR002740)
- SRA-YDG (IPR003105)
- Lon, substrate-binding domain (IPR003111)
- Uncharacterised domain CHP00451 (IPR004521)
- UPF0113, PUA domain (IPR005155)
- ASCH domain (IPR007374)
- Uncharacterised conserved protein UCP029143 (IPR008314)
- Protein of unknown function DUF984 (IPR009326)
- tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal (IPR015225)
- Uncharacterised conserved protein UCP016134 (IPR016645)
- Pheromone response, PrgU-like domain (IPR018589)
- Protein of unknown function DUF2584 (IPR019699)
- Conserved hypothetical protein CHP03684 (IPR022430)
- Uncharacterised protein family UPF0310 (IPR022996)
- Histone H3-K9 methyltransferase, plant (IPR025794)
- ATP-sulfurylase PUA-like domain (IPR025980)
- Protein CXorf40 (IPR033615)
- PUA domain superfamily (IPR036974)
- SRA-YDG superfamily (IPR036987)
- PrgU-like superfamily (IPR038201)
- Domain of unknown function DUF3850 (IPR039440)
- RlmI, PUA-like domain (IPR041532)
This superfamily represents domains with a PUA-like structure, consisting of a pseudo-barrel composed of mixed folded sheets of five strands. This structural motif is found in:
- PUA-containing proteins.
- The N-terminal of ATP sulphurylases, which contains extra structures, some similar to the PK beta-barrel domain [PMID: 11157739].
- Several bacterial hypothetical proteins, such as the N-terminal domain of YggJ [PMID: 14517985].
The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found [PMID: 10093218]. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [PMID: 16793063, PMID: 16407303]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA [PMID: 17803682]. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases [PMID: 16943774].
- SSF88697 (SSF88697)