Asp/Glu/hydantoin racemase (IPR015942)

Short name: Asp/Glu/hydantoin_racemase

Family relationships


This entry represents a group of related proteins that includes aspartate racemase, glutamate racemase, hydantoin racemase and arylmalonate decarboxylase.

Aspartate racemase (EC: and glutamate racemase (EC: are two evolutionary related bacterial enzymes that do not seem to require a cofactor for their activity [PMID: 8385993]. Glutamate racemase, which interconverts L-glutamate into D-glutamate, is required for the biosynthesis of peptidoglycan and some peptide-based antibiotics such as gramicidin S. In addition to characterised aspartate and glutamate racemases, this family also includes a hypothetical protein from Erwinia carotovora and one from Escherichia coli (ygeA).

Two conserved cysteines are present in the sequence of these enzymes. They are expected to play a role in catalytic activity by acting as bases in proton abstraction from the substrate.

GO terms

Biological Process

GO:0006807 nitrogen compound metabolic process

Molecular Function

GO:0036361 racemase activity, acting on amino acids and derivatives

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.