Family

Asp/Glu/hydantoin racemase (IPR015942)

Short name: Asp/Glu/hydantoin_racemase

Family relationships

Description

This entry represents a group of related proteins that includes aspartate racemase, glutamate racemase, hydantoin racemase and arylmalonate decarboxylase. Two conserved cysteines are present in the sequence of these enzymes. They are expected to play a role in catalytic activity by acting as bases in proton abstraction from the substrate [PMID: 17132860, PMID: 21616082].

Aspartate racemase (EC:5.1.1.13) and glutamate racemase (EC:5.1.1.3) are two evolutionary related bacterial enzymes that do not seem to require a cofactor for their activity [PMID: 8385993]. Glutamate racemase, which interconverts L-glutamate into D-glutamate, is required for the biosynthesis of peptidoglycan and some peptide-based antibiotics such as gramicidin S. In addition to characterised aspartate and glutamate racemases, this family also includes a hypothetical protein from Erwinia carotovora and one from Escherichia coli (ygeA).

Hydantoin racemases catalyze the racemization of various 5-substituted hydantoins. The structure of the allantoin racemase from Klebsiella pneumoniae has been revealed [PMID: 21616082].

GO terms

Biological Process

GO:0006807 nitrogen compound metabolic process

Molecular Function

GO:0036361 racemase activity, acting on amino acids and derivatives

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam