Domain

G-protein gamma-like domain (IPR015898)

Short name: G-protein_gamma-like_dom

Domain relationships

None.

Description

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS (regulators of G protein signaling) proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [PMID: 11331068].

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway

Molecular Function

GO:0004871 signal transducer activity

Cellular Component

GO:0005834 heterotrimeric G-protein complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam
SMART
SUPERFAMILY
PROSITE profiles