Domain

S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878)

Short name: Ado_hCys_hydrolase_NAD-bd

Domain relationships

None.

Description

S-adenosyl-L-homocysteine hydrolase (EC:3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+ as a cofactor. AdoHcyase is a highly conserved protein [PMID: 1631127] of about 430 to 470 amino acids.

This entry represents the glycine-rich region in the central part of AdoHcyase, which is thought to be involved in NAD-binding [PMID: 1631127].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam