Pathways & interactions
Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal (IPR015867)
Short name: N-reg_PII/ATP_PRibTrfase_C
- Nitrogen regulatory protein PII (IPR002187)
- Nitrogen regulatory protein P-II, urydylation site (IPR002332)
- Domain of unknown function DUF190 (IPR003793)
- Divalent ion tolerance protein, CutA (IPR004323)
- Cyclic-di-AMP receptor (IPR010375)
- Nitrogen regulatory PII-like, alpha/beta (IPR011322)
- Histidine biosynthesis HisG, C-terminal (IPR013115)
- GTP cyclohydrolase 1 type 2//Nif3, bacteria (IPR017221)
- Nitrogen regulatory protein PII, conserved site (IPR017918)
- Domain of unknown function DUF2179 (IPR019264)
- Protein of unknown function DUF3240 (IPR021634)
- Divalent cation tolerance protein CutA, Enterobacteria (IPR023700)
This entry represents a structural domain found in the nitrogen regulatory protein PII, in ATP phosphribosyltransferases (C-terminal domain), and in some bacterial hypothetical proteins. This domain consists of a ferredoxin-like alpha/beta sandwich, which forms trimeric structures with orthogonally packed beta-sheets around a three-fold axis.
PII is a tetrameric protein encoded by glnB that functions as a component of the adenylation cascade involved in the regulation of glutamine synthetase activity [PMID: 1702507]. PII helps regulate the level of glutamine synthetase in response to nitrogen source availability. In nitrogen-limiting conditions, PII is uridylylated to form PII-UMP, which allows the deadenylation of glutamine synthetase, thus activating the enzyme. Conversely, in nitrogen excess, PI-UMP is deuridylated to PII, promoting the adenylation and deactivation of glutamine synthetase [PMID: 16860774].
ATP phosphoribosyltransferase is the first enzyme of the histidine pathway. It is allosterically regulated, controlling the flow of intermediates through the pathway. The C-terminal domain is the regulatory region of the protein, which binds the allosteric inhibitor histidine [PMID: 14741209].
- G3DSA:22.214.171.124 (G3DSA:126.96.36.199)