NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (IPR015828)

Short name: NDUFA10

Overlapping homologous superfamilies

Family relationships



This entry represents the subunit 10 (also known as CI-42kD) of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). It is an accessory subunit that is believed not to be involved in catalysis [PMID: 9878551].

NADH:ubiquinone oxidoreductase (complex I) (EC: is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

GO terms

Biological Process

GO:0006120 mitochondrial electron transport, NADH to ubiquinone

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005747 mitochondrial respiratory chain complex I

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.