Family

Alpha-(1,6)-fucosyltransferase (IPR015827)

Short name: Fut8

Family relationships

None.

Description

Alpha-(1,6)-fucosyltransferase Fut8 catalyzes the alpha1,6-linkage of a fucose residue from a donor substrate to N-linked oligosaccharides on glycoproteins in a process called core fucosylation, which is crucial for growth factor receptor-mediated biological functions. Fut8-deficient mice show severe growth retardation, early death, and a pulmonary emphysema-like phenotype [PMID: 17132494]. Fut8 is also implicated to play roles in aging [PMID: 21951615] and cancer metastasis [PMID: 14568171]. It contains an N-terminal coiled-coil domain, a catalytic domain, and a C-terminal SH3 domain. The SH3 domain of Fut8 is located in the lumen and its role in glycosyl transfer is unclear [PMID: 17172260].

GO terms

Biological Process

GO:0033578 protein glycosylation in Golgi

Molecular Function

GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity

Cellular Component

GO:0032580 Golgi cisterna membrane
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF