Family

Alpha-(1,6)-fucosyltransferase, eukaryotic type (IPR015827)

Short name: Alpha1_6FUT_euk

Family relationships

None.

Description

Members of this group have enzymatic activity EC:2.4.1.68. They transfer fucose on glycoproteins to the innermost asparagine-linked N-acetylglucosamine of the chitobiose disaccharide-core unit [PMID: 10089206]. Core alpha 1,6-fucosylation is a conserved feature of animal N-linked oligosaccharides, being present in both invertebrates and vertebrates [PMID: 15604090].

All known fucosyltransferases are type II transmembrane proteins with four distinct domains: cytoplasmic, transmembrane, hypervariable, and catalytic. The catalytic domain resides in the luminal side of the trans-Golgi compartment [PMID: 2681181]. Members of this group share the conserved three alpha-6-motifs that are also present in the bacterial 6-alpha fucosyltransferases (IPR008716) [PMID: 9451017].

Disruption of the 6-alpha fucosyltransferase gene from a Chinese hamster ovary cell line has been shown to produce completely defucosylated recombinant antibodies [PMID: 15352059].

All members contain an SH3 domain (IPR001452) near the carboxyl end, but its function is unknown.

GO terms

Biological Process

GO:0033578 protein glycosylation in Golgi

Molecular Function

GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity

Cellular Component

GO:0032580 Golgi cisterna membrane
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF