3-hydroxyisobutyrate dehydrogenase-related (IPR015815)

Short name: HIBADH-related

Overlapping homologous superfamilies

Family relationships


This entry contains related reductases/dehydrogenases:

  • 3-hydroxyisobutyrate dehydrogenase (HIBADH) (EC: catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [PMID: 2647728]. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa [PMID: 1339433] (gene mmsB), it is involved in the distal valine metabolic pathway.
  • 2-hydroxy-3-oxopropionate reductase (EC: catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate.
  • 2-(hydroxymethyl)glutarate dehydrogenase (EC: catalyses the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate [PMID: 18680749].
  • L-threonate dehydrogenase catalyses oxidation of L-threonate to 2-oxo-tetronate [PMID: 27402745].
  • Putative oxidoreductase GLYR1, also known as 3-hydroxyisobutyrate dehydrogenase-like protein or nuclear protein NP60, which regulates p38 MAP kinase activity [PMID: 16352664].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.